2023 CCHIO | 宋启斌教授：新辅助放化疗联合免疫治疗值得期待，质子治疗带来新希望

2024-06-14

<p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; line-height: 1.4; color: rgba(0, 0, 0, 0.3);"><span style=";padding: 0px;outline: 0px">以下文章来源于CCMTV肺癌之音</span>&nbsp;<span style=";padding: 0px;outline: 0px">，作者V</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; line-height: 1.4; color: rgba(0, 0, 0, 0.3);"><span style=";padding: 0px;outline: 0px"><br/></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; line-height: 1.4; color: rgba(0, 0, 0, 0.3);"></p><section><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">凝聚神州，和合世界。</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">由中国抗癌协会主办，天津医科大学肿瘤医院、天津市抗癌协会、中国整合医学发展战略研究院承办的</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">2023</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">中国整合肿瘤学大会（</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">CCHIO</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">）于</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">11</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">月</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">19</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">日在天津完美收官。</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">为同步传递肿瘤学最新资讯，</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">CCMTV</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">前方报道团队深入一线，直击肿瘤学前沿进展，并且有幸邀请到</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(8, 70, 130); visibility: visible;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 11pt; font-family: 微软雅黑, sans-serif; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;">武汉大学人民医院宋启斌教授</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: 微软雅黑, sans-serif; font-size: 11pt; color: rgba(0, 0, 0, 0.9); letter-spacing: 0.034em; visibility: visible;">，就肺癌的新辅助治疗模式及质子治疗等问题进行了专访，本期整理了相关内容，以飨读者。</span></section><p><section></section></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; line-height: 1.4; color: rgba(0, 0, 0, 0.3);"><span style=";padding: 0px;outline: 0px"><br/></span></p><section><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(8, 70, 130);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 11pt; font-family: 微软雅黑, sans-serif;"></span></strong></span><section><br/></section></section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;color: rgb(8, 70, 130)"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">宋启斌教授：</span></strong></span><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">今年的ESMO会议上，报道了中山大学附属肿瘤医院一项单中心的Ⅱ期临床研究（LBA60），这项研究主要纳入可切除的Ⅱ~ⅢA期或潜在可切除的T3-4N2 ⅢB期NSCLC患者，且均无已知EGFR/ALK突变。入组患者接受SBRT（8Gy x 3次）治疗原发肿瘤，随后接受2个周期的PD-1抑制剂联合含铂双药化疗，每个周期21天。无全身性疾病进展的患者在治疗后4~6周进行手术。研究的主要终点为主要病理学缓解（MPR），次要终点包括病理完全缓解率（pCR）、R0切除率、无事件生存期（EFS）。</span></section><p><section><img class="rich_pages wxw-img" src="https://mmbiz.qpic.cn/sz_mmbiz_png/KUmHr0RAEjQC4XBNpNkxb0Tnh5OV1GaiaubVuuRta8Iic3C9raibictnlv8iaa7qQTzAiacCwr4otXeWD9qhUOl49ibicQ/640?wx_fmt=png&from=appmsg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" alt="图片"/><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;color: rgb(160, 160, 160);font-size: 14px;letter-spacing: 0.578px;font-family: 微软雅黑, sans-serif">图. SACTION-1研究设计</span></section><section><img class="rich_pages wxw-img" src="https://mmbiz.qpic.cn/sz_mmbiz_png/KUmHr0RAEjQC4XBNpNkxb0Tnh5OV1GaiaD4bXtvbgIOkmeWkGPwHIB2VKIXbatxSXUfbwWMibhGYqotZ55ibUe8Xg/640?wx_fmt=png&from=appmsg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" alt="图片"/><span style=";padding: 0px;outline: 0px;max-width: 100%;color: rgb(160, 160, 160);font-family: 微软雅黑, sans-serif;font-size: 14px;letter-spacing: 0.578px;box-sizing: border-box !important;overflow-wrap: break-word !important">图.&nbsp;</span><span style=";padding: 0px;outline: 0px;max-width: 100%;color: rgb(160, 160, 160);font-family: 微软雅黑, sans-serif;font-size: 14px;letter-spacing: 0.578px;box-sizing: border-box !important;overflow-wrap: break-word !important">SACTION-1</span><span style=";padding: 0px;outline: 0px;max-width: 100%;color: rgb(160, 160, 160);font-family: 微软雅黑, sans-serif;font-size: 14px;letter-spacing: 0.578px;box-sizing: border-box !important;overflow-wrap: break-word !important">研究主要和次要终点</span></section><section></section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">结果显示，患者的MPR率为76.1%，pCR率为52.2%，这一数据高于过去免疫联合化疗新辅助治疗的MPR率及pCR率，获益趋势在PD-L1低表达的人群中更加明显。此外，由于放疗具有远隔效应，大部分患者的淋巴结转移情况能够得到改善，并且安全性良好。但是，这项研究仅仅进行了两周期术前联合治疗，并且只是初步临床研究数据。<span style=";padding: 0px;outline: 0px;max-width: 100%;font-size: 15px;color: rgb(8, 70, 130);box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important">因此，这种治疗模式的疗效及安全性能否超越标准的新辅助治疗模式（CheckMate816模式），仍然需要更多研究数据和临床实践来证实。</strong></span></span><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 15px;letter-spacing: 0.034em">对于可切除的肺癌患者，我们的治疗目标是实现长期生存，因此形成了目前的免疫</span><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 15px;letter-spacing: 0.034em">+</span><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 15px;letter-spacing: 0.034em">化疗的围术期治疗模式。</span><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 15px;letter-spacing: 0.034em">虽然疗效较过去有提高，但仍然不尽如人意，我们希望通过大分割放疗的介入，提高治疗的反应率，改善新辅助治疗的效果。</span><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 15px;letter-spacing: 0.034em">虽然整体思路是正确的，但在临床实践中，能否实现较好的安全性及疗效，仍然是未来需要探索的方向。</span></section></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;color: rgba(0, 0, 0, 0.9);font-family: system-ui, -apple-system, BlinkMacSystemFont, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-wrap: wrap;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 15px;letter-spacing: 0.034em"><br/></span></p><p><section></section></p><p style="margin-top: 0px;margin-bottom: 24px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;color: rgba(0, 0, 0, 0.9);font-family: system-ui, -apple-system, BlinkMacSystemFont, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-wrap: wrap;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;font-family: 微软雅黑, sans-serif;color: rgb(60, 172, 163);font-size: 16px;letter-spacing: 1.5px;box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;caret-color: red"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;color: rgb(8, 70, 130)"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: system-ui, -apple-system, BlinkMacSystemFont, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;letter-spacing: 0.544px;caret-color: red;color: rgb(57, 69, 139);visibility: visible">&nbsp;</strong></span></strong></strong></strong><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;font-family: 微软雅黑, sans-serif;color: rgb(60, 172, 163);font-size: 16px;letter-spacing: 1.5px;box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;caret-color: red"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 17px;color: rgb(8, 70, 130)"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: system-ui, -apple-system, BlinkMacSystemFont, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;letter-spacing: 0.544px;caret-color: red;color: rgb(57, 69, 139);visibility: visible">质子治疗未来的发展趋势</strong></span></strong></strong></strong></span></p><p><section><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;color: rgb(8, 70, 130)"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">宋启斌教授：</span></strong></span><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">自伦琴发现X射线，至今已有130年历史，放疗技术也在不断发展进步，从最早的光子射线，比如低能X射线、普通X线、高能X线，到如今的质子重离子治疗。和过去的X线相比，质子重离子治疗具有以下几个特点。</span></section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">第一，从物理学角度而言，质子重离子治疗可以破坏DNA双链，从而直接杀伤肿瘤细胞，而光子射线只能破坏DNA单链。</span></section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">第二，从作用方式而言，质子重离子治疗可以形成<span style=";padding: 0px;outline: 0px;max-width: 100%;font-size: 15px;color: rgb(8, 70, 130);box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important">布拉格峰</strong></span>，能够在肿瘤组织附近精准释放，而不破坏周围正常组织；而光子射线不仅难以对深部肿瘤发挥作用，同时还会破坏周围正常组织。<span style=";padding: 0px;outline: 0px;max-width: 100%;font-size: 15px;color: rgb(8, 70, 130);box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important">因此，这是质子重离子治疗最大的优势</strong></span><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important">。</strong></span></section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">第三，从生物学角度而言，质子重离子治疗可以对细胞周期中的任意时相产生作用，并且对乏氧细胞和干细胞作用更加明显。</span></section></p><p style="margin-top: 0px;margin-bottom: 24px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;color: rgba(0, 0, 0, 0.9);font-family: system-ui, -apple-system, BlinkMacSystemFont, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-wrap: wrap;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 15px;font-family: 微软雅黑, sans-serif">基于质子重离子治疗在以上三个方面的优势，<span style=";padding: 0px;outline: 0px;max-width: 100%;font-size: 15px;color: rgb(8, 70, 130);box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important">其在肺癌（尤其是早期肺癌）邻域的初步临床数据优于既往的光子治疗，</strong></span>质子与光子的相对生物学效应（RBE）值的比约1：1.1~1.2，现在常用的重离子RBE值是光子的2~3倍，对癌细胞的损伤更严重。所以质子重离子治疗的前景值得期待，但目前的临床研究多为单中心、回顾性、小样本研究，未来需要更多大样本量的RCT研究进行探索，并且结合肿瘤治疗模式、精准检测等方面综合合理应用。</span></p><p><section><section><section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;color: rgb(62, 62, 62);letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;letter-spacing: 0.544px"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;color: rgb(160, 160, 160);letter-spacing: 0.578px"></strong></span></span></section></section><section><section><section><section><section>公布<img class="rich_pages wxw-img" src="https://mmbiz.qpic.cn/sz_mmbiz_jpg/KUmHr0RAEjQC4XBNpNkxb0Tnh5OV1Gaia4g7rHLCdlRFefcf28yia3RFY7m5hMAibvgBeIrwqvUjGDEeg1l7T4qpQ/640?wx_fmt=jpeg&from=appmsg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" alt="图片"/></section></section><section><section><section><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><strong style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important">宋启斌教授</strong></p></section><section><section><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">一级主任医师/教授/博士研究生导师</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">武汉大学人民医院肿瘤中心主任兼肿瘤学教研室主任</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">国家卫健委医政医管局《肺癌诊疗指南》专家组成员</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">国家癌症中心肺癌质控专家</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">中华医学会继续医学教育教材《肺癌》分册副主编</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">中国医师协会肿瘤多学科诊疗专业委员会副主任委员兼总干事</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">世界华人肿瘤医师协会常委兼胸部肿瘤分会副主任委员</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">中国医促会胸部肿瘤分会 副主任委员</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">中国临床肿瘤学会（CSCO）常务理事</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">CSCO老年肿瘤专委会副主委，肺癌、大数据专委会&nbsp; 常委</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">中国抗癌协会肺癌、肿瘤多学科诊疗专委会 常委</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">湖北省临床肿瘤学会（ESCO）理事长兼肺癌专委员会主任委员</span></p><p style="margin-top: 0px;margin-bottom: 0px;padding: 0px;outline: 0px;max-width: 100%;clear: both;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important"><span style=";padding: 0px;outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-family: 微软雅黑, sans-serif;font-size: 11px">武汉医学会放射肿瘤治疗学分会 主任委员</span></p></section></section><section><section><section><section><br/></section></section></section></section></section></section></section></section></section><section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;color: rgb(0, 0, 0);font-family: -apple-system-font, system-ui, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important">审</span><span style=";padding: 0px;outline: 0px;max-width: 100%;color: rgb(0, 0, 0);font-family: -apple-system-font, system-ui, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important">核｜宋启斌</span><span style=";padding: 0px;outline: currentcolor none 0px;max-width: 100%;color: rgb(0, 0, 0);font-family: -apple-system-font, system-ui, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important">教授</span></section><section><span style=";padding: 0px;outline: 0px;max-width: 100%;color: rgb(0, 0, 0);font-family: -apple-system-font, system-ui, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important">责编｜赵德云、叶静&nbsp;&nbsp;</span><span style=";padding: 0px;outline: currentcolor none 0px;max-width: 100%;color: rgb(0, 0, 0);font-family: -apple-system-font, system-ui, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important">编辑｜V</span></section></section></section></section></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; line-height: 1.4; color: rgba(0, 0, 0, 0.3);"><br/></p>